Long-term sustained weight loss appears to be associated with significant reduction of atrial fibrillation (AF) burden with improved maintenance of sinus rhythm in obese patients, new data presented at the American College of Cardiology (ACC) Scientific Sessions 2015 indicate.
In addition, obese patients with AF who lost at least 10% of their body weight appear to be six times more likely to achieve long-term freedom from AF compared with those who did not lose weight.
Although previous studies have shown that weight loss can reduce the burden of AF, it was unknown if the effect was sustained, if there is a dose effect or if weight fluctuations mattered. This current study is the first to track the long-term effects of weight loss and the degree of weight fluctuation on AF burden.
Results suggest that patients who lost more weight and maintained a more stable weight over 4 years showed marked reductions in AF burden and severity — the study’s primary endpoints.